13 posts tagged with "architecture"

In a single development session, we shipped three phases of a cognitive architecture that transforms Abby from a stateless RAG chatbot into a persistent, intelligent, context-aware research assistant. She now remembers who you are, routes complex questions to a more powerful brain, traverses clinical concept hierarchies, and warns you when your data has gaps. This post tells the complete story — the problems we solved, the architecture we built, and the engineering decisions behind 188 passing tests across 60+ new files.

Today we gave Parthenon's AI assistant a research library that most outcomes researchers would envy. Abby — our context-aware, privacy-preserving AI — now has 115,000+ SapBERT-embedded vectors spanning 2,258 peer-reviewed OHDSI papers, the complete Book of OHDSI, documentation from 30 HADES R packages, a decade of community forum Q&A, and 19 medical reference textbooks covering epidemiology, biostatistics, pharmacology, pathology, and clinical medicine.

This post tells the full story: why we built Abby, how the architecture works, what we harvested, what we learned about data quality in knowledge bases, and where we're headed next.

We ran every analysis type in Parthenon — estimation, prediction, SCCS, evidence synthesis, pathways, characterization, and incidence rates — against our full Acumenus CDM with 1 million synthetic patients. Thirteen seeded analyses. Seven different OHDSI methodologies. One session.

This post covers what happened when we moved from the 2,694-patient Eunomia demo dataset to production scale, the bugs that only surface at a million patients, and the hard-won lessons about propensity score modeling on synthetic data.